Prostafexin is a scientifically validated and standardized herbal formulation already established for centuries. One of the components achieve dual 5α-reductase/PDE5 inhibition thus, countering the ED effect of 5α-reductase inhibition. Another component specifically blocks α1A-adrenoceptor signalling, causing relaxation of the smooth muscle tissue in the prostate and bladder neck, thus, improving urinary flow and reduces lower urinary tract symptoms. Another component also modulates TGF-β/SMAD3-driven fibroblast-to-myofibroblast transition and collagen deposition and lastly, Bcl-2 upregulation, and Wnt/β-catenin/mTOR inhibition is achieved by the last component specifically adapted from MyoFibrox. The restoration of apoptosis drives regression. Patients on Prostafexin are also advised to take Sphenolax which reverses the Metabolic driver of BPH via hyperinsulinemia. Using this protocol, full reversal of established hyperplastic and fibrotic remodelling has been achieved in human patients.
Myofibrox is a proprietary blend of four herbs with definitive action on four key pathological drivers of uterine fibroids. The first component antagonizes progesterone/PR-A/PR signaling. The second component is a dual inhibitor of intratumoral aromatase and 17β-HSD1.
Beyond any tissue-specific proliferative signals that drives oncogenesis, all pathways must ultimately cascade to cell-cycle; thus, our proprietary Atxilox is a carefully blended botanicals which specifically inhibits CDK4/6-cyclin D-Rb, recovers mitochondrial apoptosis evasion via Bcl-2/Bcl-xL/Mcl-1, XIAP/survivin downregulation and blockage of VEGF/VEGFR angiogenesis which sustains tumour vasculature.
In cancer patients, metastasis begins when cells at the primary tumour switch from a stable, cohesive state to an invasive one driven principally by hypoxia, inflammation and a stiffening, fibrotic stroma. Hypoxia stabilises HIF-1α, and together with TGF-β, Wnt and NF-κB signalling this activates EMT transcription factors (Snail, Twist, ZEB1). These repress E-cadherin, so cells lose adhesion to neighbours, gain a mesenchymal, motile phenotype, and acquire stem-like and survival traits.
